The spider infestation continues as all human beings in New York city starts turning into real life human sized spiders with furs and fangs. Even the avenger Hawkeye is not spared as he turned into one. Spiderman has problems of his own when his girlfriend also turned into a spider and blend in with the rest leaving Spiderman unable to locate which one is her. There is a background introduction to the villain behind all this, Adriana Soria aka the Queen a super powered being who have fought with Spiderman and Captain America.
The anti-venom is the one with the cure as his name suggests. Venom now a government agent confronts the anti-venom to bring him in to provide the cure. The bad blood between the symbiotes nearly makes venom kills anti-venom. Lots of characters involved here with the X-men Emma Frost, Strom and Gambit having to deal with the onslaught.Meanwhile the mayor Jonah Jameson is freaking out as scrambles to find a cure before he himself turned to a spider. The mayor is desperate enough to get the help of the spider slayer who have in the past killed Jameson's wife. The spider slayer starts taunting about the desperation of Jameson but that is the biggest mistake he will make as the Queen starts controlling Jameson's mind turning him into a crazed spider which eventually bites the spider slayer dead as Spiderman watch helplessly.
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